CAS number : 5119-48-2

Plant source : Withania somnifera

Withaferin A is a steroidal lactone isolated from Winter cherry (Withania somnifera) and is the first member of the withanolides to be discovered. Withaferin A is a potent inhibitor of angiogenesis (the formation of new blood vessels). Withaferin A inhibits both NF-κB and Sp1 Transcription factor activity. Withaferin A also down regulates VEGF gene expression and can affect calcium signaling.